Skuespillerne i GTA: San Andreas består av både kjente og relativt ukjente navn. Hovedpersonen, CJ, spilles av rapperen Chris Bellard, som vanligvis går under artistnavnet Young Maylay. Han får følge av en rekke mer eller mindre kjente rappere, som MC Eiht, Yo-Yo, Kid Frost, Big Boy og The Game. I tillegg spiller Ice-T rapperen Mad Dogg.
Den korrupte politimannen Officer Tenpenny spilles av alltid like geniale Samuel L. Jackson, som nok må sies å være den mest kjente skuespilleren her. Partneren hans spilles av Chris Penn, som er bror til Sean Penn og best kjent for sin innsats i Reservoir Dogs. Peter Fonda (sønn av Henry, bror til Jane og far til Bridget og Justin) spiller en hippie som går under navnet "The Truth".
Komikeren David Cross spiller en nerdete butikkeier, mens Charlie Murphy har f ått rollen som halliken med det suverene navnet Jizzy B. James Wood spiller Mike Toreno, mens Debi Mazar, som spilte Maria i GTA 3, spiller også her en karakter ved navn Maria (om det er samme karakter som hun spilte i GTA 3 er uklart).
Som kjent foregår GTA: San Andreas i 1992, og musikken som spilles på radioen reflekterer dette. I forhold til musikkstiler, ser det ut som vi også denne gangen får rimelig mye variasjon. Overraskende nok er det ingen åttitallsstasjon med denne gangen, men til gjengjeld får vi for første gang cruise i en "lowrider" med Willie Nelson på full guffe. Det burde bli temmelig heftig.
Her er den fullstendige låtlisten:
Radio Los Santos
Stil: Samtids-Hip-Hop
DJ: Julio G
1. Too Short "The Ghetto"
2. 2 Pac "I Don't Give a F***"
3. Compton's Most Wanted "Hood Took Me Under"
4. Dr. Dre "Nuthin' But A "G" Thang"
5. Dr. Dre "F*** Wit Dre Day"
6. Dr. Dre "Deep Cover"
7. Kid Frost "La Raza"
8. Cypress Hill "How I Could Just Kill a Man"
9. The D.O.C. "It's Funky Enough"
10. NWA "Alwayz Into Somethin'"
11. NWA "Express Yourself"
12. Ice Cube "It Was a Good Day"
13. Ice Cube "Check Yo Self (The Message Remix)"
14. Eazy-E "Eazy-Er Said Than Dunn"
15. Above The Law "Murder Rap"
16. Da Lench Mob "Guerillas in Tha Mist"
Bounce FM
Stil: Funk
DJ: "The Funktipus" (spilt av George Clinton)
1. Zapp "I Can Make You Dance"
2. Kool & The Gang "Hollywood Swingin'"
3. Ohio Players "Love Rollercoaster"
4. Rick James "Cold Blooded"
5. Maze "Twilight"
6. Fatback "Yum Yum"
7. The Isley Brothers "Between the Sheets"
8. Ronnie Hudson "West Coast Poplock"
9. Lakeside "Fantastic Voyage"
10. George Clinton "Loopzilla"
11. Dazz Band "Let It Whip"
12. Cameo "Candy"
13. Ohio Players "Funky Worm"
14. MFSB "Love Is The Message"
15. Johnny Harris "Odyssey"
16. Roy Ayers "Running Away"
17. The Gap Band "You Dropped A Bomb On Me"
CSR 103.2
Stil: Samtidssoul
DJ: Philip "PM" Michaels (spilt av Michael Bivins)
1. SWV "I'm So Into You"
2. Soul II Soul "Keep On Movin"
3. Samuelle "So You Like What You See"
4. En Vogue "My Lovin' (Never Gonna Get It)"
5. Johnny Gill "Rub You The Right Way"
6. Ralph Tresvant "Sensitivity"
7. Guy "Groove Me"
8. Aaron Hall "Don't Be Afraid"
9. Boyz II Men "Motownphilly"
10. Bell Biv Devoe (BBD) "Poison"
11. Today "I Got The Feeling"
12. Wreck-N-Effect "New Jack Swing"
13. Bobby Brown "Don't Be Cruel"
Playback FM
Stil: Klassisk Hip-Hop
DJ: Forth Right MC (spilt av Chuck D)
1. Kool G Rap & DJ Polo "Road to the Riches"
2. Big Daddy Kane "Warm It Up Kane"
3. Spoonie Gee "The Godfather"
4. Masta Ace "Me & The Biz"
5. Slick Rick "Children's Story"
6. Public Enemy "Rebel Without a Pause"
7. Eric B. & Rakim "I Know You Got Soul"
8. Rob Base & DJ EZ Rock "It Takes Two"
9. Gang Starr "B.Y.S"
10. Biz Markie "The Vapors"
11. Brand Nubian "Brand Nubian"
12. Ultramagnetic MC's "Critical Beatdown"
MasterSounds 98.3
Stil: Rare Groove
DJ: Johnny "The Love Giant" Parkinson (spilt av Ricky Harris)
1. Charles Wright "Express Yourself"
2. Maceo & The Macks "Cross The Tracks (We Better Go Back)"
3. Harlem Underground Band "Smokin' Cheeba Cheeba"
4. The Chakachas "Jungle Fever"
5. Bob James "Nautilus"
6. Booker T & The MG's "Green Onions"
7. The Blackbyrds "Rock Creek Park"
8. Bobby Byrd "Hot Pants"
9. Bobby Byrd "I Know You Got Soul"
10. James Brown "Funky President"
11. James Brown "The Payback"
12. Lyn Collins "Think About It"
13. Lyn Collins "Rock Me Again And Again"
14. Maceo & The Macks "Soul Power 74"
15. The J.B.'s "Grunt"
16. War "Low Rider"
17. Gloria Jones "Tainted Love"
18. Sir Joe Quarterman "(I Got) So Much Trouble In My Mind"
K-JAH West
Stil: Dub/Reggae
DJ's: Marshall Peters (spilt av Lowell "Sly" Dunbar) Johnny Lawton (spilt av Robert "Robbie" Shakespeare)
1. Black Harmony "Don't let It Go To Your Head"
2. Blood Sisters "Ring My Bell"
3. Shabba Ranks "Wicked Inna Bed"
4. Buju Banton "Batty Rider"
5. Augustus Pablo "King Tubby Meets Rockers Uptown"
6. Dennis Brown "Revolution"
7. Willie William "Armagideon Time"
8. I Roy "Sidewalk Killer"
9. Toots & The Maytals "Funky Kingston"
10. Dillinger "Cocaine In My Brain"
11. The Maytals "Pressure Drop"
12. The Pliers "Bam Bam"
13. Barrington Levy "Here I Come"
14. Reggie Stepper "Drum Pan Sound"
15. Black Uhuru "Great Train Robbery"
16. Max Romeo & The Upsetters "Chase The Devil"
K-DST
Stil: Klassisk rock
DJ: Tommy "The Nightmare" Smith (spilt av W. Axl Rose)
1. Foghat "Slow Ride"
2. Creedence Clearwater Revival "Green River"
3. Heart "Barracuda"
4. Kiss "Strutter"
5. Toto "Hold The Line"
6. Rod Stewart "Young Turks"
7. Tom Petty "Running Down A Dream"
8. Joe Cocker "Woman to Woman"
9. Humble Pie "Get Down To It"
10. Grand Funk Railroad "Some Kind of Wonderful"
11. Lynyrd Skynyrd "Free Bird"
12. America "A Horse With No Name"
13. The Who "Eminence Front"
14. Boston "Smokin'"
15. David Bowie "Somebody Up There Likes Me"
16. Eddie Money "Two Tickets To Paradise"
17. Billy Idol "White Wedding"
Radio X: The Alternative
Stil: Moderne rock
DJ: Sage (spilt av Jodie Shawback)
1. Helmet "Unsung"
2. Depeche Mode "Personal Jesus"
3. Faith No More "Midlife Crisis"
4. Danzig "Mother"
5. Living Colour "Cult of Personality"
6. Primal Scream "Movin On Up"
7. Guns N' Roses "Welcome to the Jungle"
8. L7 "Pretend We're Dead"
9. Ozzy Osbourne "Hellraiser"
10. Soundgarden "Rusty Cage"
11. Rage Against The Machine "Killing In The Name"
12. Jane's Addiction "Been Caught Stealing"
13. The Stone Roses "Fools Gold"
14. Alice In Chains "Them Bones"
15. Stone Temple Pilots "Plush"
K-ROSE
Stil: Country
DJ: Mary-Beth Maybell (spilt av Riette Burdick)
1. Jerry Reed "Amos Moses"
2. Conway Twitty & Loretta Lynn"Louisiana Woman, Mississippi Man"
3. Hank Williams "Hey Good Lookin'"
4. Juice Newton "Queen of Hearts"
5. Asleep At The Wheel "The Letter That Johnny Walker Read"
6. The Desert Rose Band "One Step Forward"
7. Willie Nelson "Crazy"
8. Pasty Cline "Three Cigarettes in the Ashtray"
9. Mickey Gilley "Make The World Go Away"
10. Ed Bruce "Mama Don't Let Your Babies Grow Up To Be Cowboys"
11. Merle Haggard "Always Wanting You"
12. Whitey Shafer "All My Exes Live In Texas"
13. Eddie Rabbit "I Love A Rainy Night"
14. Statler Brothers "New York City"
15. Statler Brothers "Bed of Roses"
SF-UR
Stil: House
DJ: Hans Oberlander (spilt av Lloyd Floyd)
1. Jomanda "Make My Body Rock"
2. 808 State "Pacific"
3. The Todd Terry Project "Weekend"
4. Nightwriters "Let The Music (Use You)"
5. Marshall Jefferson "Move Your Body"
6. Maurice "This Is Acid"
7. Mr. Fingers "Can You Feel It?"
8. A Guy Called Gerald "Voodoo Ray" 9. Cultural Vibe "Ma Foom Bey"
10. Ce Ce Rogers "Someday"
11. Robert Owens "I'll Be Your Friend"
12. Frankie Knuckles "Your Love"
13. Joe Smooth "Promised Land"
14. 28th Street Crew "I Need A Rhythm"
15. Raze "Break 4 Love"
16. Fallout "The Morning After"
